The old sink has 4 faucet holes, 4" apart. So, a new 2-handle faucet with
sprayer should fit OK.

Will any of the 1-handle (Delta-style) faucets with sprayer fit proper
on such a sink, with the base covering the extra holes?

Thx,
Cathy

They have some that will have a base to cover up the extra hole and
they also make soap dispensers that fit in the extra hole. What you
are trying to do is not uncommon. Go look at some at the home
improvement type store and you will find something that will work.
Tell your friend Willie as well.