Chris wrote:
I am about to paint the trim in my stairway.. It has 2-3 coats of
paint. I know the top coat is a latex paint, and the bottom is lead
paint.. I did a swab test and found it out.

What would be best after washing down with a non-soapy detergent- a
light sanding, or using liquid sandpaper? I am going from a medium
blue to a bright semi-gloss white. Would priming be necessary?

1. Latex doesn't sand so use TSP ("liquid sandpaper") to kill any gloss.

2. No primer needed, it already has paint. You may need 2 coats of top
paint to hide the blue.

Opinion: putting latex on wood should be a flogging offense.

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dadiOH
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