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UK diy (uk.d-i-y) For the discussion of all topics related to diy (do-it-yourself) in the UK. All levels of experience and proficency are welcome to join in to ask questions or offer solutions. |
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OT June Statins Thread
Crops up regularly, always gets response, so here goes:
Statins and Musculoskeletal Conditions, Arthropathies, and Injuries ONLINE FIRST Ishak Mansi, MD; Christopher R. Frei, PharmD, MSc; Mary Jo Pugh, PhD; Una Makris, MD; Eric M. Mortensen, MD, MSc JAMA Intern Med. 2013;():1-9. doi:10.1001/jamainternmed.2013.6184 Importance Statin use may be associated with increased musculoskeletal adverse events, especially in physically active individuals. Objective To determine whether statin use is associated with musculoskeletal conditions, including arthropathy and injury, in a military health care system. Design A retrospective cohort study with propensity score matching. Setting San Antonio Military Multi-Market. Participants Tricare Prime/Plus beneficiaries evaluated from October 1, 2003, to March 1, 2010. Interventions Statin use during fiscal year 2005. On the basis of medication fills, patients were divided into 2 groups: statin users (received a statin for at least 90 days) and nonusers (never received a statin throughout the study period). Main Outcomes and Measures Using patients' baseline characteristics, we generated a propensity score that was used to match statin users and nonusers; odds ratios (ORs) were determined for each outcome measure. Secondary analyses determined adjusted ORs for all patients who met study criteria and a subgroup of patients with no comorbidities identified using the Charlson Comorbidity Index. Sensitivity analysis further determined adjusted ORs for a subgroup of patients with no musculoskeletal diseases at baseline and a subgroup of patients who continued statin therapy for 2 years or more. The occurrence of musculoskeletal conditions was determined using prespecified groups of International Classification of Diseases, Ninth Revision, ClinicalModification codes: Msk1, all musculoskeletal diseases; Msk1a, arthropathies and related diseases; Msk1b, injury-related diseases (dislocation, sprain, strain); and Msk2, drug-associated musculoskeletal pain. Results A total of 46 249 individuals met study criteria (13 626 statin users and 32 623 nonusers). Of these, we propensity score–matched 6967 statin users with 6967 nonusers. Among matched pairs, statin users had a higher OR for Msk1 (OR, 1.19; 95% CI, 1.08-1.30), Msk1b (1.13; 1.05-1.21), and Msk2 (1.09; 1.02-1.18); the OR for Msk1a was 1.07 (0.99-1.16; P = .07). Secondary and sensitivity analyses revealed higher adjusted ORs for statin users in all outcome groups. Conclusions and Relevance Musculoskeletal conditions, arthropathies, injuries, and pain are more common among statin users than among similar nonusers. The full spectrum of statins' musculoskeletal adverse events may not be fully explored, and further studies are warranted, especially in physically active individuals. http://archinte.jamanetwork.com/arti...icleid=1691918 -- Rod |
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OT June Statins Thread
?
Why here? Brian -- From the Sofa of Brian Gaff Reply address is active "polygonum" wrote in message ... Crops up regularly, always gets response, so here goes: Statins and Musculoskeletal Conditions, Arthropathies, and Injuries ONLINE FIRST Ishak Mansi, MD; Christopher R. Frei, PharmD, MSc; Mary Jo Pugh, PhD; Una Makris, MD; Eric M. Mortensen, MD, MSc JAMA Intern Med. 2013;():1-9. doi:10.1001/jamainternmed.2013.6184 Importance Statin use may be associated with increased musculoskeletal adverse events, especially in physically active individuals. Objective To determine whether statin use is associated with musculoskeletal conditions, including arthropathy and injury, in a military health care system. Design A retrospective cohort study with propensity score matching. Setting San Antonio Military Multi-Market. Participants Tricare Prime/Plus beneficiaries evaluated from October 1, 2003, to March 1, 2010. Interventions Statin use during fiscal year 2005. On the basis of medication fills, patients were divided into 2 groups: statin users (received a statin for at least 90 days) and nonusers (never received a statin throughout the study period). Main Outcomes and Measures Using patients' baseline characteristics, we generated a propensity score that was used to match statin users and nonusers; odds ratios (ORs) were determined for each outcome measure. Secondary analyses determined adjusted ORs for all patients who met study criteria and a subgroup of patients with no comorbidities identified using the Charlson Comorbidity Index. Sensitivity analysis further determined adjusted ORs for a subgroup of patients with no musculoskeletal diseases at baseline and a subgroup of patients who continued statin therapy for 2 years or more. The occurrence of musculoskeletal conditions was determined using prespecified groups of International Classification of Diseases, Ninth Revision, ClinicalModification codes: Msk1, all musculoskeletal diseases; Msk1a, arthropathies and related diseases; Msk1b, injury-related diseases (dislocation, sprain, strain); and Msk2, drug-associated musculoskeletal pain. Results A total of 46 249 individuals met study criteria (13 626 statin users and 32 623 nonusers). Of these, we propensity score–matched 6967 statin users with 6967 nonusers. Among matched pairs, statin users had a higher OR for Msk1 (OR, 1.19; 95% CI, 1.08-1.30), Msk1b (1.13; 1.05-1.21), and Msk2 (1.09; 1.02-1.18); the OR for Msk1a was 1.07 (0.99-1.16; P = .07). Secondary and sensitivity analyses revealed higher adjusted ORs for statin users in all outcome groups. Conclusions and Relevance Musculoskeletal conditions, arthropathies, injuries, and pain are more common among statin users than among similar nonusers. The full spectrum of statins' musculoskeletal adverse events may not be fully explored, and further studies are warranted, especially in physically active individuals. http://archinte.jamanetwork.com/arti...icleid=1691918 -- Rod |
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OT June Statins Thread
On 08/06/2013 10:20, Brian Gaff wrote:
? Why here? Brian Because in early May there was a long and involved thread about statins which seem to be of interest to many. The demographics of this group (from my perception) suggest that statins will have been offered to a large proportion of correspondents. -- Rod |
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OT June Statins Thread
polygonum wrote:
On 08/06/2013 10:20, Brian Gaff wrote: ? Why here? Brian Because in early May there was a long and involved thread about statins which seem to be of interest to many. The demographics of this group (from my perception) suggest that statins will have been offered to a large proportion of correspondents. In the UK, as a matter of policy, *all* adult diabetics are pushed onto statins as early as possible unless they show contra-indictaing side effects. The theory is that, as far as cardiac health is concerned, being diabetic is equivalent to having had your first heart attack. -- Tciao for Now! John. |
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OT June Statins Thread
On Sat, 08 Jun 2013 10:48:00 +0100, John Williamson wrote:
polygonum wrote: On 08/06/2013 10:20, Brian Gaff wrote: ? Why here? Brian Because in early May there was a long and involved thread about statins which seem to be of interest to many. The demographics of this group (from my perception) suggest that statins will have been offered to a large proportion of correspondents. In the UK, as a matter of policy, *all* adult diabetics are pushed onto statins as early as possible unless they show contra-indictaing side effects. The theory is that, as far as cardiac health is concerned, being diabetic is equivalent to having had your first heart attack. Although they are now backtracking on this one last I heard (although I am struggling to remember why). Something about the risks of a heart attack in diabetics not being caused by the same factors as the risks in one-attack non-diabetics. Another fine example of correlation not implying causation. However they are now suggesting statins for everyone because the reckon that the industry deserves the money - ...ummmm.. - the number and seriousness of heart attacks avoided is more than the number and seriousness of side effects. Allegedly. Oh, and what happened to a small dose of aspirin every day? IIRC that was a suggestion when I was first diagnosed. Cheers Dave R |
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OT June Statins Thread
David.WE.Roberts wrote:
However they are now suggesting statins for everyone what happened to a small dose of aspirin every day? And a low dose of ACE inhibitor, or rolling all three into a "polypill" |
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OT June Statins Thread
On 08/06/2013 13:29, David.WE.Roberts wrote:
Oh, and what happened to a small dose of aspirin every day? IIRC that was a suggestion when I was first diagnosed. My mother is now on 75mg aspirin having (apparently, allegedly) having had a heart attack while in hospital for something else entirely. So she also was prescribed omeprazole to "protect and line" her stomach and prevent the aspirin causing any bleeding. And one of her other medicines also tends to reduce clotting and hence make any bleeds more likely to continue. And they insist on Simvastatin. I did argue against omeprazole and, so long as she does not get heartburn/reflux more than twice a week, they accepted her stopping that. Now around two weeks off it and the only slight issue was on the second or third day after stopping. So stomach issues are a reason. -- Rod |
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OT June Statins Thread
On Sat, 08 Jun 2013 08:55:37 +0100, polygonum wrote:
Crops up regularly, always gets response, so here goes: Statins and Musculoskeletal Conditions, Arthropathies, and Injuries ONLINE FIRST Ishak Mansi, MD; Christopher R. Frei, PharmD, MSc; Mary Jo Pugh, PhD; Una Makris, MD; Eric M. Mortensen, MD, MSc JAMA Intern Med. 2013;():1-9. doi:10.1001/jamainternmed.2013.6184 Importance Statin use may be associated with increased musculoskeletal adverse events, especially in physically active individuals. Objective To determine whether statin use is associated with musculoskeletal conditions, including arthropathy and injury, in a military health care system. Design A retrospective cohort study with propensity score matching. Setting San Antonio Military Multi-Market. Participants Tricare Prime/Plus beneficiaries evaluated from October 1, 2003, to March 1, 2010. Interventions Statin use during fiscal year 2005. On the basis of medication fills, patients were divided into 2 groups: statin users (received a statin for at least 90 days) and nonusers (never received a statin throughout the study period). Main Outcomes and Measures Using patients' baseline characteristics, we generated a propensity score that was used to match statin users and nonusers; odds ratios (ORs) were determined for each outcome measure. Secondary analyses determined adjusted ORs for all patients who met study criteria and a subgroup of patients with no comorbidities identified using the Charlson Comorbidity Index. Sensitivity analysis further determined adjusted ORs for a subgroup of patients with no musculoskeletal diseases at baseline and a subgroup of patients who continued statin therapy for 2 years or more. The occurrence of musculoskeletal conditions was determined using prespecified groups of International Classification of Diseases, Ninth Revision, ClinicalModification codes: Msk1, all musculoskeletal diseases; Msk1a, arthropathies and related diseases; Msk1b, injury-related diseases (dislocation, sprain, strain); and Msk2, drug-associated musculoskeletal pain. Results A total of 46 249 individuals met study criteria (13 626 statin users and 32 623 nonusers). Of these, we propensity score€“matched 6967 statin users with 6967 nonusers. Among matched pairs, statin users had a higher OR for Msk1 (OR, 1.19; 95% CI, 1.08-1.30), Msk1b (1.13; 1.05-1.21), and Msk2 (1.09; 1.02-1.18); the OR for Msk1a was 1.07 (0.99-1.16; P = .07). Secondary and sensitivity analyses revealed higher adjusted ORs for statin users in all outcome groups. Conclusions and Relevance Musculoskeletal conditions, arthropathies, injuries, and pain are more common among statin users than among similar nonusers. The full spectrum of statins' musculoskeletal adverse events may not be fully explored, and further studies are warranted, especially in physically active individuals. http://archinte.jamanetwork.com/arti...icleid=1691918 Thanks - interesting stuff and uk.d-i-y is IMHO a good place to post OT stuff :-) My brain fried early on with the big words. Are they saying that they managed to select two matching groups with the same condition (presumably high cholesterol) where one group had statin therapy and the other didn't? Does make me wonder how they treated the control group - or why they didn't. Otherwise there would be the issue of underlying conditions linked to the requirement for statins. OTOH isn't it generally accepted that some statins (such as Symvastatin) do have adverse side effects for a number of users (myself included before I stopped using them)? In which case this is just confirming what the brochure with the pills tells you. The brochure for Pravastatin says that more than one in 1,000 people may suffer from side effects including muscle and joint pain, with more serious side effects for more than 1 in 10,000 people. So is the research highlighting something more significant than that published by the drug manufacturer? Cheers Dave R |
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OT June Statins Thread
On 08/06/2013 13:40, David.WE.Roberts wrote:
On Sat, 08 Jun 2013 08:55:37 +0100, polygonum wrote: Crops up regularly, always gets response, so here goes: Statins and Musculoskeletal Conditions, Arthropathies, and Injuries ONLINE FIRST Ishak Mansi, MD; Christopher R. Frei, PharmD, MSc; Mary Jo Pugh, PhD; Una Makris, MD; Eric M. Mortensen, MD, MSc JAMA Intern Med. 2013;():1-9. doi:10.1001/jamainternmed.2013.6184 Importance Statin use may be associated with increased musculoskeletal adverse events, especially in physically active individuals. Objective To determine whether statin use is associated with musculoskeletal conditions, including arthropathy and injury, in a military health care system. Design A retrospective cohort study with propensity score matching. Setting San Antonio Military Multi-Market. Participants Tricare Prime/Plus beneficiaries evaluated from October 1, 2003, to March 1, 2010. Interventions Statin use during fiscal year 2005. On the basis of medication fills, patients were divided into 2 groups: statin users (received a statin for at least 90 days) and nonusers (never received a statin throughout the study period). Main Outcomes and Measures Using patients' baseline characteristics, we generated a propensity score that was used to match statin users and nonusers; odds ratios (ORs) were determined for each outcome measure. Secondary analyses determined adjusted ORs for all patients who met study criteria and a subgroup of patients with no comorbidities identified using the Charlson Comorbidity Index. Sensitivity analysis further determined adjusted ORs for a subgroup of patients with no musculoskeletal diseases at baseline and a subgroup of patients who continued statin therapy for 2 years or more. The occurrence of musculoskeletal conditions was determined using prespecified groups of International Classification of Diseases, Ninth Revision, ClinicalModification codes: Msk1, all musculoskeletal diseases; Msk1a, arthropathies and related diseases; Msk1b, injury-related diseases (dislocation, sprain, strain); and Msk2, drug-associated musculoskeletal pain. Results A total of 46 249 individuals met study criteria (13 626 statin users and 32 623 nonusers). Of these, we propensity score€“matched 6967 statin users with 6967 nonusers. Among matched pairs, statin users had a higher OR for Msk1 (OR, 1.19; 95% CI, 1.08-1.30), Msk1b (1.13; 1.05-1.21), and Msk2 (1.09; 1.02-1.18); the OR for Msk1a was 1.07 (0.99-1.16; P = .07). Secondary and sensitivity analyses revealed higher adjusted ORs for statin users in all outcome groups. Conclusions and Relevance Musculoskeletal conditions, arthropathies, injuries, and pain are more common among statin users than among similar nonusers. The full spectrum of statins' musculoskeletal adverse events may not be fully explored, and further studies are warranted, especially in physically active individuals. http://archinte.jamanetwork.com/arti...icleid=1691918 Thanks - interesting stuff and uk.d-i-y is IMHO a good place to post OT stuff :-) My brain fried early on with the big words. Are they saying that they managed to select two matching groups with the same condition (presumably high cholesterol) where one group had statin therapy and the other didn't? Does make me wonder how they treated the control group - or why they didn't. Otherwise there would be the issue of underlying conditions linked to the requirement for statins. OTOH isn't it generally accepted that some statins (such as Symvastatin) do have adverse side effects for a number of users (myself included before I stopped using them)? In which case this is just confirming what the brochure with the pills tells you. The brochure for Pravastatin says that more than one in 1,000 people may suffer from side effects including muscle and joint pain, with more serious side effects for more than 1 in 10,000 people. So is the research highlighting something more significant than that published by the drug manufacturer? Cheers Dave R There seem to be some extra things like dislocation, sprain and strain. Plus the specific association between amount of exercise and likelihood of one of the identified issues occurring. Obviously that is of particular significance to the military. The current Patient Information Leaflets in the UK seem to be word-for-word identical except for things like maker's name, ingredients, etc. http://www.medicines.org.uk/emc/sear...=Qui ckSearch -- Rod |
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OT June Statins Thread
In message , polygonum
writes On 08/06/2013 10:20, Brian Gaff wrote: ? Why here? Brian Because in early May there was a long and involved thread about statins which seem to be of interest to many. The demographics of this group (from my perception) suggest that statins will have been offered to a large proportion of correspondents. My fault! It seemed a fitting subject for our age group and I'd rather ask opinions of friends/aquaintances than strangers. Currently I am reaching the end of a *two week off* followed by *two weeks on* to try and spot any side effects. The next part of the plan is to halve the dose and then get another blood test. I may try to get my insulin levels checked as there seems to be some linkage. -- Tim Lamb |
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OT June Statins Thread
snip OTOH isn't it generally accepted that some statins (such as Symvastatin) do have adverse side effects for a number of users (myself included before I stopped using them)? In which case this is just confirming what the brochure with the pills tells you. The brochure for Pravastatin says that more than one in 1,000 people may suffer from side effects including muscle and joint pain, with more serious side effects for more than 1 in 10,000 people. So is the research highlighting something more significant than that published by the drug manufacturer? Cheers Dave R Every year when I have my review for my (alleged) high blood pressure, the doctor recommends to the practice nurse that handles the review, that I start on statins for what she considers to be cholesterol problems, and what I consider to be a slightly (against the average) elevated level. And every year I refuse them. It's reached the point now where the nurse says "Doctor xxx has recommended that you start on statins, but you're not going to do that, are you ...?" I don't tolerate medication well in the first place. I went through a lot of different types of blood pressure medication before we finally found one that didn't have significant side effects - to the point where I was almost saying "enough already !" I have a friend who was started on blood pressure meds, and he got side effects, but didn't shout about it loud enough. Bit by bit, they've added all sorts of odds and sods to what they've got him taking for perceived conditions, and he is now a bloody wreck compared to the fit and vital person he was before they got started. He has now completely lost his sense of taste, and shakes all the time. Sometimes, I think you are better off living with the risks than using long term meds to try to eliminate them. I also think that a lot of the 'life-threatening' conditions that they insist on trying to treat you for, are just fads. Arfa |
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OT June Statins Thread
"Arfa Daily" wrote:
snip OTOH isn't it generally accepted that some statins (such as Symvastatin) do have adverse side effects for a number of users (myself included before I stopped using them)? In which case this is just confirming what the brochure with the pills tells you. The brochure for Pravastatin says that more than one in 1,000 people may suffer from side effects including muscle and joint pain, with more serious side effects for more than 1 in 10,000 people. So is the research highlighting something more significant than that published by the drug manufacturer? Cheers Dave R Every year when I have my review for my (alleged) high blood pressure, the doctor recommends to the practice nurse that handles the review, that I start on statins for what she considers to be cholesterol problems, and what I consider to be a slightly (against the average) elevated level. And every year I refuse them. It's reached the point now where the nurse says "Doctor xxx has recommended that you start on statins, but you're not going to do that, are you ...?" I don't tolerate medication well in the first place. I went through a lot of different types of blood pressure medication before we finally found one that didn't have significant side effects - to the point where I was almost saying "enough already !" I have a friend who was started on blood pressure meds, and he got side effects, but didn't shout about it loud enough. Bit by bit, they've added all sorts of odds and sods to what they've got him taking for perceived conditions, and he is now a bloody wreck compared to the fit and vital person he was before they got started. He has now completely lost his sense of taste, and shakes all the time. Sometimes, I think you are better off living with the risks than using long term meds to try to eliminate them. I also think that a lot of the 'life-threatening' conditions that they insist on trying to treat you for, are just fads. Arfa +1 A lot of medicine is driven by the desire of drug companies to get all of us on drugs for life. With that in mind, we all have a duty to be as critical as possible about the whole life benefits and risks of such treatment. I feel well, consequently I do not participate in any "well man" clinics, nor do I allow anyone to even measure my BP without a dammed good clinical indication. Tim |
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OT June Statins Thread
On Sun, 09 Jun 2013 02:06:01 +0100, Arfa Daily wrote:
I don't tolerate medication well in the first place. I went through a lot of different types of blood pressure medication before we finally found one that didn't have significant side effects - to the point where I was almost saying "enough already !" AOL to that. I'm now on a small clutch of meds for high BP, that I can actually tolerate - and they might even be helping my BP! I have a friend who was started on blood pressure meds, and he got side effects, but didn't shout about it loud enough. Bit by bit, they've added all sorts of odds and sods to what they've got him taking for perceived conditions, and he is now a bloody wreck compared to the fit and vital person he was before they got started. He has now completely lost his sense of taste, and shakes all the time. Is he on amlodipine? I was given that about five years ago, in the search for BP meds that would work. After three months I had a distressing range of symptoms, from tingling arms and legs, a sore patch on the gum line, and loss of taste and smell. When I complained I was taken off it, and some of the symptoms disappeared right away (taste and smell), some took months to lessen, and I've still got the sore patch (although successive dentists can find nothing wrong). The other thing I'd say, about statins, is that I found a lunch-time sandwich made using Flora margarine brought by cholesterol down from 7.4 to 5.2 units, low enough for me to argue that I didn't need statins - so this could be an easy route to try first. -- Terry Fields |
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OT June Statins Thread
On 09/06/2013 08:44, Tim+ wrote:
I feel well, consequently I do not participate in any "well man" clinics, nor do I allow anyone to even measure my BP without a dammed good clinical indication. Am happy enough for them to satisfy themselves by measuring it. (Not a big enough issue to argue about.) But absolutely never would I allow a single reading in a surgery setting to dictate any treatment of me. We have our own BP machine and I would at the very least use that repeatedly over hours, days, weeks. And might well ask for a 24-hour or longer monitor. -- Rod |
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OT June Statins Thread
On Sunday, June 9, 2013 8:53:42 AM UTC+1, polygonum wrote:
On 09/06/2013 08:44, Tim+ wrote: I feel well, consequently I do not participate in any "well man" clinics, nor do I allow anyone to even measure my BP without a dammed good clinical indication. Am happy enough for them to satisfy themselves by measuring it. (Not a big enough issue to argue about.) But absolutely never would I allow a single reading in a surgery setting to dictate any treatment of me. We have our own BP machine and I would at the very least use that repeatedly over hours, days, weeks. And might well ask for a 24-hour or longer monitor. -- Rod Statins (allegedly) help in the prevention of heart attacks. I don't think they do b....r all for you once you've had one. The great cholesterol myth is just that and there seems as much valid, research results out to prove the argument either way, too much of the stuff kills you/it occurs naturally, does no harm and we need it. I was one of the 1 in a 1000 and statins caused so much damage the neurologist thought I had rapid onset MS. We actually argued about the statins. I stopped taking them. One month later, no muscle pain, brain fog cleared, short term memory improved, stutter vanished, and I was able to walk without a stick....etc. The neurologist was impressed but wouldn't accept it was anything to do with the medication - "fairy dust then" I told him. I'm now on a non statin based medication, available from your GP, but you have to ask/demand/insist on it. I've heard of or know several folk who have had various issues clear up once they dropped the statins. |
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OT June Statins Thread
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OT June Statins Thread
On 09/06/2013 08:53, polygonum wrote:
On 09/06/2013 08:44, Tim+ wrote: I feel well, consequently I do not participate in any "well man" clinics, nor do I allow anyone to even measure my BP without a dammed good clinical indication. Am happy enough for them to satisfy themselves by measuring it. (Not a big enough issue to argue about.) But absolutely never would I allow a single reading in a surgery setting to dictate any treatment of me. We have our own BP machine and I would at the very least use that repeatedly over hours, days, weeks. And might well ask for a 24-hour or longer monitor. I did that intensive self-monitoring for a few months (well, I love spreadsheets) and what became clear was that the evening readings were higher. Now I always have BP checked at the doc's first thing in the morning, which keeps them quiet. Currently on 5mg amlodipine with no side effects |
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OT June Statins Thread
stuart noble wrote:
On 09/06/2013 08:53, polygonum wrote: On 09/06/2013 08:44, Tim+ wrote: I feel well, consequently I do not participate in any "well man" clinics, nor do I allow anyone to even measure my BP without a dammed good clinical indication. Am happy enough for them to satisfy themselves by measuring it. (Not a big enough issue to argue about.) But absolutely never would I allow a single reading in a surgery setting to dictate any treatment of me. We have our own BP machine and I would at the very least use that repeatedly over hours, days, weeks. And might well ask for a 24-hour or longer monitor. I did that intensive self-monitoring for a few months (well, I love spreadsheets) and what became clear was that the evening readings were higher. Now I always have BP checked at the doc's first thing in the morning, which keeps them quiet. Currently on 5mg amlodipine with no side effects "No noticeable side effects YET" I think you mean. ;-) Tim |
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OT June Statins Thread
On 09/06/13 02:06, Arfa Daily wrote:
snip OTOH isn't it generally accepted that some statins (such as Symvastatin) do have adverse side effects for a number of users (myself included before I stopped using them)? In which case this is just confirming what the brochure with the pills tells you. The brochure for Pravastatin says that more than one in 1,000 people may suffer from side effects including muscle and joint pain, with more serious side effects for more than 1 in 10,000 people. So is the research highlighting something more significant than that published by the drug manufacturer? Cheers Dave R Every year when I have my review for my (alleged) high blood pressure, the doctor recommends to the practice nurse that handles the review, that I start on statins for what she considers to be cholesterol problems, and what I consider to be a slightly (against the average) elevated level. And every year I refuse them. It's reached the point now where the nurse says "Doctor xxx has recommended that you start on statins, but you're not going to do that, are you ...?" I don't tolerate medication well in the first place. I went through a lot of different types of blood pressure medication before we finally found one that didn't have significant side effects - to the point where I was almost saying "enough already !" I have a friend who was started on blood pressure meds, and he got side effects, but didn't shout about it loud enough. Bit by bit, they've added all sorts of odds and sods to what they've got him taking for perceived conditions, and he is now a bloody wreck compared to the fit and vital person he was before they got started. He has now completely lost his sense of taste, and shakes all the time. Sometimes, I think you are better off living with the risks than using long term meds to try to eliminate them. I also think that a lot of the 'life-threatening' conditions that they insist on trying to treat you for, are just fads. Arfa +1 I am down to one ACE inhibitor, and sod the rest. I feel a lot better than when I was on a cocktail of hypertensions and statins. In the end I was actually feeling suicidal. :Life was simply too much like hard work. That's when I stopped. Now life is great again. Ther is a difference between 20 years of hell and 10-15 years of possibly having heart problems. But feeling alive. -- Ineptocracy (in-ep-toc-ra-cy) €“ a system of government where the least capable to lead are elected by the least capable of producing, and where the members of society least likely to sustain themselves or succeed, are rewarded with goods and services paid for by the confiscated wealth of a diminishing number of producers. |
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OT June Statins Thread
On 09/06/2013 13:03, The Natural Philosopher wrote:
Ther is a difference between 20 years of hell and 10-15 years of possibly having heart problems. But feeling alive. You seem to be allowed to choose not to be treated for cancer, to refuse an operation or a blood transfusion, but refusal of questionable medicines with many known side-effects is turned back on you as being un-co-operative. I completely agree with you that it should be, and is, your choice. The medics might have a duty to offer things, to explain side-effects and risks, etc. - but it is patient's choice. -- Rod |
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OT June Statins Thread
On 09/06/2013 12:53, Tim+ wrote:
stuart noble wrote: On 09/06/2013 08:53, polygonum wrote: On 09/06/2013 08:44, Tim+ wrote: I feel well, consequently I do not participate in any "well man" clinics, nor do I allow anyone to even measure my BP without a dammed good clinical indication. Am happy enough for them to satisfy themselves by measuring it. (Not a big enough issue to argue about.) But absolutely never would I allow a single reading in a surgery setting to dictate any treatment of me. We have our own BP machine and I would at the very least use that repeatedly over hours, days, weeks. And might well ask for a 24-hour or longer monitor. I did that intensive self-monitoring for a few months (well, I love spreadsheets) and what became clear was that the evening readings were higher. Now I always have BP checked at the doc's first thing in the morning, which keeps them quiet. Currently on 5mg amlodipine with no side effects "No noticeable side effects YET" I think you mean. ;-) Tim Thanks for that :-) |
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OT June Statins Thread
stuart noble wrote:
On 09/06/2013 12:53, Tim+ wrote: stuart noble wrote: On 09/06/2013 08:53, polygonum wrote: On 09/06/2013 08:44, Tim+ wrote: I feel well, consequently I do not participate in any "well man" clinics, nor do I allow anyone to even measure my BP without a dammed good clinical indication. Am happy enough for them to satisfy themselves by measuring it. (Not a big enough issue to argue about.) But absolutely never would I allow a single reading in a surgery setting to dictate any treatment of me. We have our own BP machine and I would at the very least use that repeatedly over hours, days, weeks. And might well ask for a 24-hour or longer monitor. I did that intensive self-monitoring for a few months (well, I love spreadsheets) and what became clear was that the evening readings were higher. Now I always have BP checked at the doc's first thing in the morning, which keeps them quiet. Currently on 5mg amlodipine with no side effects "No noticeable side effects YET" I think you mean. ;-) Tim Thanks for that :-) You're welcome. ;-) The fact of the matter is that if these drugs really do make you live longer, you can look forward to dying of cancer or dementia instead. Tim |
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OT June Statins Thread
On 09/06/2013 15:04, Tim+ wrote:
The fact of the matter is that if these drugs really do make you live longer, you can look forward to dying of cancer or dementia instead. I think I remember reading something like an average of 14 days. Which didn't seem a lot when the adverse effects are taken into account. (There again, I might already have dementia and be mis-remembering what I read...) -- Rod |
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OT June Statins Thread
On 09/06/2013 15:04, Tim+ wrote:
stuart noble wrote: On 09/06/2013 12:53, Tim+ wrote: stuart noble wrote: On 09/06/2013 08:53, polygonum wrote: On 09/06/2013 08:44, Tim+ wrote: I feel well, consequently I do not participate in any "well man" clinics, nor do I allow anyone to even measure my BP without a dammed good clinical indication. Am happy enough for them to satisfy themselves by measuring it. (Not a big enough issue to argue about.) But absolutely never would I allow a single reading in a surgery setting to dictate any treatment of me. We have our own BP machine and I would at the very least use that repeatedly over hours, days, weeks. And might well ask for a 24-hour or longer monitor. I did that intensive self-monitoring for a few months (well, I love spreadsheets) and what became clear was that the evening readings were higher. Now I always have BP checked at the doc's first thing in the morning, which keeps them quiet. Currently on 5mg amlodipine with no side effects "No noticeable side effects YET" I think you mean. ;-) Tim Thanks for that :-) You're welcome. ;-) The fact of the matter is that if these drugs really do make you live longer, you can look forward to dying of cancer or dementia instead. Tim Don't overlook dying of boredom, which I consider the most likely |
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OT June Statins Thread
stuart noble wrote:
On 09/06/2013 15:04, Tim+ wrote: stuart noble wrote: On 09/06/2013 12:53, Tim+ wrote: stuart noble wrote: On 09/06/2013 08:53, polygonum wrote: On 09/06/2013 08:44, Tim+ wrote: I feel well, consequently I do not participate in any "well man" clinics, nor do I allow anyone to even measure my BP without a dammed good clinical indication. Am happy enough for them to satisfy themselves by measuring it. (Not a big enough issue to argue about.) But absolutely never would I allow a single reading in a surgery setting to dictate any treatment of me. We have our own BP machine and I would at the very least use that repeatedly over hours, days, weeks. And might well ask for a 24-hour or longer monitor. I did that intensive self-monitoring for a few months (well, I love spreadsheets) and what became clear was that the evening readings were higher. Now I always have BP checked at the doc's first thing in the morning, which keeps them quiet. Currently on 5mg amlodipine with no side effects "No noticeable side effects YET" I think you mean. ;-) Tim Thanks for that :-) You're welcome. ;-) The fact of the matter is that if these drugs really do make you live longer, you can look forward to dying of cancer or dementia instead. Tim Don't overlook dying of boredom, which I consider the most likely Yep. My wife has a100 yr old aunt doing that. Very sad. Tim |
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OT June Statins Thread
I have a friend who was started on blood pressure meds, and he got side
effects, but didn't shout about it loud enough. Bit by bit, they've added all sorts of odds and sods to what they've got him taking for perceived conditions, and he is now a bloody wreck compared to the fit and vital person he was before they got started. He has now completely lost his sense of taste, and shakes all the time. Sometimes, I think you are better off living with the risks than using long term meds to try to eliminate them. I also think that a lot of the 'life-threatening' conditions that they insist on trying to treat you for, are just fads. Hypertension is no Fad at all Arfa, its a very prevalent and real problem. I have and I know quite a few who are thus afflicted, and yes you are right that some tolerate some drugs better then others. And sometimes more than the one drug is a very good idea to come at it from more then the one treatment angle. What is also a known is not all doctors are the same and I had a total incompetent who didn't pick up the hypertension at all for severe recurrent headaches instead got me addicted to Ergotamine and some others that didn't do any good at all. At SWMBO's insistence I did consult another GP and she picked up this straightaway treated the HT and lo and behold the almost daily headaches I did suffer from disappeared and a vast reduction hypertension figures Also not all hospital dept's are the same, some are better than others.... Arfa -- Tony Sayer |
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OT June Statins Thread
In article , stuart noble
scribeth thus On 09/06/2013 08:53, polygonum wrote: On 09/06/2013 08:44, Tim+ wrote: I feel well, consequently I do not participate in any "well man" clinics, nor do I allow anyone to even measure my BP without a dammed good clinical indication. Am happy enough for them to satisfy themselves by measuring it. (Not a big enough issue to argue about.) But absolutely never would I allow a single reading in a surgery setting to dictate any treatment of me. We have our own BP machine and I would at the very least use that repeatedly over hours, days, weeks. And might well ask for a 24-hour or longer monitor. I did that intensive self-monitoring for a few months (well, I love spreadsheets) and what became clear was that the evening readings were higher. Thats par for the course or condition;!.. Now I always have BP checked at the doc's first thing in the morning, which keeps them quiet. Well its best checked over the whole day and averaged out but the idea is not to just keep the doctor quiet its to keep you well Currently on 5mg amlodipine with no side effects Its good that combined with something like Candesartan.. -- Tony Sayer |
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OT June Statins Thread
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OT June Statins Thread
I'm just back from a week's holiday, having forgotten to pack my
statins, and the only difference I've noticed is that the weather is better when I don't take them. -- Reentrant |
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OT June Statins Thread
"polygonum" wrote in message ... On 09/06/2013 13:03, The Natural Philosopher wrote: Ther is a difference between 20 years of hell and 10-15 years of possibly having heart problems. But feeling alive. You seem to be allowed to choose not to be treated for cancer, to refuse an operation or a blood transfusion, but refusal of questionable medicines with many known side-effects is turned back on you as being un-co-operative. I completely agree with you that it should be, and is, your choice. The medics might have a duty to offer things, to explain side-effects and risks, etc. - but it is patient's choice. -- Rod It's a difficult line to draw. Whilst I have a degree of respect for health professionals' skills and qualifications, I am also not 'scared' of them, and am prepared to say that I'm not happy, if I'm not. After all, it is my body, and I expect to have a degree of say in how it is treated. The thing is that these days, there is a wealth of knowledge to be had on the 'net about every possible health complaint and its potential treatments, and provided that you have a reasonable level of education, and a basic understanding of your body's function, I see no reason why you shouldn't feel justified in challenging some aspects of proposed treatments. There are many factors that drive a clinician's choice of treatment, not the least of which can be cost. The first one to have a go at me about my blood pressure, was the senior practice nurse. She started me off on whatever is the cheapest and most common treatment. It didn't do a lot to alter my blood pressure, but what it did do in spades, was make me tired, and give me an odd feeling of being 'detached' from my body. I told her this, and she insisted that tiredness was not a known side effect of this particular drug. Having carefully read the blurb sheet that came with it, and having read up on the 'net about it, I knew otherwise, so I said "well... I think you'll find that it is ..." She grabbed up her drugs 'bible', and spent a couple of minutes studying it, then slammed it shut and banged it down on her desk, and proceeded to prescribe something different. From that point on, we had a slightly uneasy 'standoff', but at least she listened. I didn't like her, and it was clear that she didn't like me, and these days, she basically won't see me. We went through a lot of different drugs before finally arriving at Candesarten, which seemed to work in a mild dose, and gave me no noticeable side effects. However, from what I understand, it is a Japanese drug, manufactured under license by one company in France, and hence expensive, which I honestly believe was a major factor in it taking so long to arrive at it. A while back, the local HA wrote to me and said that because of the expense of that drug, everyone on it was going to be moved to a substitute called Losarten Potassium. I was prepared for a fight if necessary, but changed to it with an open mind, and as it happened, it seemed slightly more efficacious and again has had no noticeable side effects. The nurse that I see now, and have done for several years, gets on ok with me, and always listens to any concerns that I have. I think that she has accepted that I have a fairly deep interest in and understanding of my body and any conditions that it suffers from, and is prepared to deal with me on that basis. She makes her recommendations, often based on what the doctor has said, but never tries to force anything on me. That's the way I like it, and that's the way I think it *should* be. Sadly, for my mate, that's not the way it works in the relationship between him and his practice nurse, and despite him making noises about side effects, they have refused to change his medication. He is now in such a state that recently, they were concerned that he might be beginning to suffer from Parkinson's. He had all the tests done, but they declared him clear of any identifiable neurological conditions. So they've decided that it's a condition called essential tremor, and are now medicating him for this as well. And in my opinion, he continues to get worse. He is now almost unrecognisable from the person that I have known for the better part of 40 years, and whilst it may be just a case of 'getting old', all of this only started when they began treating him for his blood pressure ... Arfa |
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OT June Statins Thread
"tony sayer" wrote in message ... I have a friend who was started on blood pressure meds, and he got side effects, but didn't shout about it loud enough. Bit by bit, they've added all sorts of odds and sods to what they've got him taking for perceived conditions, and he is now a bloody wreck compared to the fit and vital person he was before they got started. He has now completely lost his sense of taste, and shakes all the time. Sometimes, I think you are better off living with the risks than using long term meds to try to eliminate them. I also think that a lot of the 'life-threatening' conditions that they insist on trying to treat you for, are just fads. Hypertension is no Fad at all Arfa, its a very prevalent and real problem. I have and I know quite a few who are thus afflicted, and yes you are right that some tolerate some drugs better then others. And sometimes more than the one drug is a very good idea to come at it from more then the one treatment angle. What is also a known is not all doctors are the same and I had a total incompetent who didn't pick up the hypertension at all for severe recurrent headaches instead got me addicted to Ergotamine and some others that didn't do any good at all. At SWMBO's insistence I did consult another GP and she picked up this straightaway treated the HT and lo and behold the almost daily headaches I did suffer from disappeared and a vast reduction hypertension figures Also not all hospital dept's are the same, some are better than others.... Tony Sayer I don't have any truck with the condition of hypertension existing, Tony. Where I do have a bit of a problem is with the degree of health risk that seems to have been attached to it in recent years, and the lack of concensus on what constitutes 'high' blood pressure. Last Christmas, I had an episode of cellulitis in my leg, which necessitated seven weeks of treatment with oral antibiotics, and weekly visits to the surgery to check progress. Inevitably, one of the visits corresponded to a day off of my usual doctor, so I got to see a young and very 'modern' Indian doctor who was standing in. He impressed me, I have to say, and one of the things he did was to take my blood pressure, using a proper manual sphigmo' rather than an auto. My usual doctor had not actually checked my blood pressure on any of the four or five previous visits to date for my leg, despite it being a declared a long-term issue on my record. He was perfectly satisfied with the reading he got, and said that it would actually be even slightly lower, when my body wasn't still fighting the leg infection. The next week, I saw my usual doctor again, and this time, she actually did take my pressure, again using the manual sphigmo'. The reading was about 2 points different on the systolic, and about the same on the diastolic as it had been the previous week when the other doctor had said it was fine. However, this doctor immediately started going on about it being too high. She asked me when my next prescription was due. I told her two weeks, so she said that from the next day, she wanted me to start taking two pills a day, and that she would do me a new prescription there and then for pills of double the concentration. I was horrified at this and asked for the justification in DOUBLING the dose. Other than her opinion that my blood pressure was "too high", she had none. I respectfully declined, and told her that I would not even consider messing with my blood pressure medication, whilst she was still working on clearing up another condition with vicious doses of antibiotics. I put it to her that as someone who also makes a living by diagnosis, I had a cardinal rule that only one thing should be changed at a time in order to understand the effects of that change. I told her that this rule had served me well for over forty years in my career, and that I was going to apply it here as well. She grudgingly accepted the logic of my argument, and said that if I felt that I didn't want to go into it further at this point, then I could leave it alone. So I did ... Arfa |
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OT June Statins Thread
On 10/06/2013 02:15, Arfa Daily wrote:
Sadly, for my mate, that's not the way it works in the relationship between him and his practice nurse, and despite him making noises about side effects, they have refused to change his medication. He is now in such a state that recently, they were concerned that he might be beginning to suffer from Parkinson's. He had all the tests done, but they declared him clear of any identifiable neurological conditions. So they've decided that it's a condition called essential tremor, and are now medicating him for this as well. And in my opinion, he continues to get worse. He is now almost unrecognisable from the person that I have known for the better part of 40 years, and whilst it may be just a case of 'getting old', all of this only started when they began treating him for his blood pressure ... In my area of interest, many patients are told that there is only one medicine. Repeatedly. And despite the patient knowing full well it is an option. You can easily look at any copy of BNF and see Liothyronine alongside Levothyroxine as possible hypothyroidism treatments. Sometimes doctors still deny it exists. Not as if it were a new medicine - synthesised in, IIRC 1953, and available fairly shortly after. Once the doctor has been forced to accept its existence, they refuse on grounds of not knowing anything about it, cost (which is ridiculously high in the UK), etc. There have been situations in which GPs have refused to continue prescribing Liothyronine even when consultants have decided it is necessary. At least one such ended up with the consultant ringing up the GP and threatening him with GMC report for failing to look after patient. Ten years ago (approx.) my partner suffered a collapse into severe hypothyroidism. At the time much was made of her age and the need to accept the effects of aging. Now, treating herself and virtually never seeing a doctor, she is in many ways healthier than she was then. -- Rod |
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OT June Statins Thread
In message ,
Reentrant writes I'm just back from a week's holiday, having forgotten to pack my statins, and the only difference I've noticed is that the weather is better when I don't take them. When asked, my doctor said it takes two weeks for the body to *normalise* after stopping statins. After reading TNP's view of the drugs I decided to carry out my own self assessment trial. After 2 weeks I felt less vague aches/non specific back pain, slept better and found more enthusiasm to get stuff done:-) This coincided with some better weather and getting some major jobs done so hard to be certain. Now, nearly at the end of the two weeks back on statins, I dream more/vividly, tend to wake over hot after only 5 hours sleep but haven't yet noticed any unearned aches and pains. My plan is to halve the dose and get my levels checked after another couple of weeks. I will also ask about possible links with thyroid issues but expect to get fobbed off. -- Tim Lamb |
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OT June Statins Thread
On 10/06/2013 08:51, Tim Lamb wrote:
I will also ask about possible links with thyroid issues but expect to get fobbed off. As near certain as anything in medicine. "What link? There is no link." "The one in the patient information leaflet." "Yes, well, they include everything that has ever been reported there. Couldn't possibly happen to you." -- Rod |
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OT June Statins Thread
In message , polygonum
writes On 10/06/2013 08:51, Tim Lamb wrote: I will also ask about possible links with thyroid issues but expect to get fobbed off. As near certain as anything in medicine. "What link? There is no link." "The one in the patient information leaflet." "Yes, well, they include everything that has ever been reported there. Couldn't possibly happen to you." :-) Googleitis. The medical profession have an unbridled hatred for the information revolution! Somewhere I spotted that an under active thyroid can lead the liver to overproduce cholesterol.... -- Tim Lamb |
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OT June Statins Thread
On 10/06/2013 10:16, Tim Lamb wrote:
In message , polygonum writes On 10/06/2013 08:51, Tim Lamb wrote: I will also ask about possible links with thyroid issues but expect to get fobbed off. As near certain as anything in medicine. "What link? There is no link." "The one in the patient information leaflet." "Yes, well, they include everything that has ever been reported there. Couldn't possibly happen to you." :-) Googleitis. The medical profession have an unbridled hatred for the information revolution! Somewhere I spotted that an under active thyroid can lead the liver to overproduce cholesterol.... Back in the earlier part of the twentieth century (i.e. before current blood tests had been developed), high cholesterol was taken as a strong indicator of inadequate thyroid hormone levels. Ironically, they now rely very largely on the Thyroid Stimulating Hormone test which is roundly condemned by many, including the person who developed the TSH test! It is far too prone to produce false negatives for lots of reasons and, as soon as any supplementation is occurring (e.g. on levothyroxine), its value is seriously questionable. Even the reference ranges are unacceptably wide. And then doctors look at a test result of, say, 5.0 (maybe range 0.5 to 4.5), and say they will not treat until TSH rises to 10. They want their cake and to eat it. You simply cannot have ranges which you hold as absolute and then ignore them! -- Rod |
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OT June Statins Thread
On 10/06/2013 11:54, Huge wrote:
My GP is perfectly happy if I turn up with a good idea what's wrong with me. I suspect things may be different when people turn up with disrupted chakras or discoloured auras. I have seen several people posting that they have been expressly told by their doctor(s) NOT to search anywhere. Makes you wonder who the NHS websites are aimed at? Mind, at least one person retorted that it would be impossible not to look. With which I agree. -- Rod |
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OT June Statins Thread
"polygonum" wrote in message ... On 10/06/2013 11:54, Huge wrote: My GP is perfectly happy if I turn up with a good idea what's wrong with me. I suspect things may be different when people turn up with disrupted chakras or discoloured auras. I have seen several people posting that they have been expressly told by their doctor(s) NOT to search anywhere. Makes you wonder who the NHS websites are aimed at? Mind, at least one person retorted that it would be impossible not to look. With which I agree. -- Rod I find that a lot of the best descriptions of conditions, and information on the methods and drugs used to treat them, originate in the American healthcare system. They seem to have a more 'open' view of the doctor - patient relationship than we do. Possibly because it is fundamentally a private system ? Arfa |
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OT June Statins Thread
On 10/06/2013 13:06, Arfa Daily wrote:
"polygonum" wrote in message ... On 10/06/2013 11:54, Huge wrote: My GP is perfectly happy if I turn up with a good idea what's wrong with me. I suspect things may be different when people turn up with disrupted chakras or discoloured auras. I have seen several people posting that they have been expressly told by their doctor(s) NOT to search anywhere. Makes you wonder who the NHS websites are aimed at? Mind, at least one person retorted that it would be impossible not to look. With which I agree. -- Rod I find that a lot of the best descriptions of conditions, and information on the methods and drugs used to treat them, originate in the American healthcare system. They seem to have a more 'open' view of the doctor - patient relationship than we do. Possibly because it is fundamentally a private system ? Arfa I am a regular visitor to the National Institutes of Health! And other USA and other country sites. Get a bit sick of the "Am I not the most wonderful doctor in the world?" sites (espeically the ones who have so obviously bought into a "program" and end up with nearly word-for-word identical text) - but not difficult to ignore once you are familiar. :-) Perhaps surprisingly, I have also found some interesting and useful information by using Google translated searches - e.g Russian, German, Chinese, etc. -- Rod |
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OT June Statins Thread
polygonum :
On 10/06/2013 11:54, Huge wrote: My GP is perfectly happy if I turn up with a good idea what's wrong with me. I suspect things may be different when people turn up with disrupted chakras or discoloured auras. I have seen several people posting that they have been expressly told by their doctor(s) NOT to search anywhere. Makes you wonder who the NHS websites are aimed at? Obviously doctors vary and what you describe is certainly not NHS policy. SWMBO is a GP and one of her favourite consultation moves is to ask the patient what they think the problem is. And she Googles stuff in the surgery with the patient watching. -- Mike Barnes |
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