On Tue, 30 Mar 2021 14:26:45 +0100, John Rumm
wrote:

On 30/03/2021 11:44, T i m wrote:

One for the medical people ... As more and more people take the jab I
was wondering if there are any stats that cover what sort of reaction
they may have to one and why that might be?

eg. We both had the AZ jab (she's had both now) and neither of us had
any reaction at all.

In contrast, a mate, his Mrs and their friend all had theirs and all
three suffered ranging reactions from headaches, overall aching to
nausea etc?

All of the above are possible...

Ok.

(I had my first one this morning, so I will find out which if any kick
in for me!)

Cool. A live study. ;-)

As I understand it, the vaccine (most vaccines) start building our own
antibodies by exposing them to an inactive version of the target virus
(profile?)

Sometimes it's an attenuated or weakened version of the actual pathogen
(or possibly a genetically engineered version with its "payload"
removed), but more commonly its just a part of it - typically some of
the surface proteins since these will be what the immune system will
"see" first following infection.

Understood.

in readiness for the real / active virus and it's likely
that it's that load on our bodies that causes some of these reactions?

Yup - some of the symptoms we associate with "infection" like raised
temperature etc are just those of the bodies immune system "activating".

But can some people have these things going on and not experience any
noticeable reaction whilst other do then?

So assuming it is (and not just an allergic reaction etc) if you don't
have any reaction symptoms at all, could it be you haven't been given
the vaccine (a placebo, I'm not suggesting this likely in this case),
that you already had sufficient antibodies for some reason (previous
similar viral infection or just because) so the body didn't react ...

AIUI, if you already have some antibodies to the pathogen then you are
more likely to have a more noticeable reaction to the vaccine - as it
will be "recognised" and provoke a more direct response.

Ah, ok, that makes sense. A bigger gun to fight back with etc.

So for people who have already had a similar infection they may get a
more noticeable response to the first vaccine. For others who have not
been previously exposed, they may get more response to the second.

Ok (and explains why a second jab as mentioned elsewhere might create
a greater action).

your body doesn't actually react (create antibodies), effectively
meaning that you are no better protected or you just happen to have a
different physiology to those who do seem to have more prominent
symptoms, where the same things are going on re antibody generation
but your body can do it 'easily'?

Some people seem to have less response than others anyway. Older people
tend to have less response. With some vaccines that can mean that they
are less effective in older people, however with the current covid ones,
that does not appear to be the cases. They have all been shown to
provoke very strong antibody response across all the age groups,
regardless of the reaction experienced by the recipient.

Ok thanks. Please let us know how you feel over the next 24 hours. ;-)

Cheers, T i m