On Wed, 07 Feb 2018 21:02:34 -0000, "James Wilkinson Sword"
wrote:

I've never heard "loused up" before. Where does that come from?

WWI, It refers to being full of lice (Plural, louse), common in the
trenches. That is also where "cooties" came from.
Now it is just anything that seems screwed up.