Ignoramus13722 fired this volley in
:

http://igor.chudov.com/tmp/150-Ton-Hydraulic-Press/

Well, I'd say (just from the pictures) that you don't have any issues with
the top of the frame. Dunno what the bottom beam will take with a point
load at the middle (which is your worst-case load).

There are nice beam deflection calculators on the web for free use, and for
fatigue life, figure a maximum deflection at the middle of about 1/16".

It would take more, but figure conservatively for long life.

Lloyd