i think it would lower homes value, if you do it at least leave the
plumbing in place take photos of open walls etc so the next owner can
put it back easily.

how long are you planning on living there? if its forever do what makes
you happy. if its move in 5 years do whats better for homes value

you might check with a local realtor, if all the nearby homes have this
bath removing it could make it hard to sell