John Pilhoefer wrote:

I guess I should have given an example in my initial post.

My latest project is a cabinet with 12 pull handles. Of the 12 handles there
are three different designs with 3 different hole patterns.

So I am drilling 24 holes. ...

One answer--VIX self-centering bit...

Second answer--make alignment jig(s)

Third answer--there are a myriad of "self-centering" jigs for the
precise purpose...