orangetrader wrote:
I have a metal rack that is 24" wide and 48" tall, it is a metal
modular rack with various attachments - hooks, shelves, knobs
etc...and has four attachment holes on the vertical edges of the
frame. Ideally I would like to attach drill four screws through the
holes into the wall studs. But of course the studs are 16" apart,
and I can't even position it such that one side of the frame will
match up with the frame because I like to center it and align it with
a door adjacent to it such that when the door is fully opened it will
cover up the rack on the wall.

I can use toggle bolts but I don't think the drywall will have enough
strength. I thought about cutting two pieces of wood and mount it
horizontally into the studs above and below, and then screw two
vertical pieces to them to form a frame, but this will not be
symmetrical.

Any idea?

The toggle bolts - in your configuration - will hold several hundred pounds.