Jay-n-123 writes:

Which systems are more reliable, those that use R22 vs. R410a? Are
R410a systems REALLY as reliable R22?

R-22 runs at much lower pressures and systems using it are therefore
cheaper and more reliable, other things being equal. A given 410a system
could be reliable enough, but only at some higher relative cost.

410a systems only exist because of politics, not technical merits.