that doesn't sound like a good idea for a couple of reasons: The
biggest issue is that the hub probably has bosses cast in the back that
are arranged for 6 bolts. Going to a 5 bolt arrangement will compromise
things. The other issue is the hub size. Can you even get a wheel that
will fit over the hub and still pick up the new l00 mm (less than 4")
bolt pattern?

Terry Keeley wrote:

I have a 4x6 Fruehauf trailer that has 6x5" hubs (6 studs on
5" center), can I drill and tap it to 5x100mm to mount other
wheels? Will strength be compromised? I can't seem to find 5x100mm
hubs for it anywhere and adapters are $100 each...